Duo return from injury as Wanderers square up to Saracens in semi-final
Painter is back from a calf injury, while Sleightholme has recovered from an ankle problem, with both players able to start against Saracens Storm at Allianz Park.
The Wanderers have made a total of six changes to their line-up as they head into their fourth successive semi-final appearance.
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Hide AdJames Grayson captains the side from fly-half for the fourth straight game, while Charlie Davies is back at scrum-half.
Will Davis joins Painter in the front row, and soon-to-be Saint Tui Uru starts in the No.8 shirt.
Bedford Blues lock Will Carrick-Smith completes the sextet of changes to the Wanderers side as he makes a guest appearance in black, green and gold to complete the tight five.
There are a total of seven guest players in the Wanderers squad.
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Hide AdAs for Saracens, they name two future Saints players on their bench, with scrum-half Henry Taylor and centre Reuben Bird-Tulloch both among the replacements.
Ex-Saints Academy wing Rotimi Segun is the only change to the back-line which helped secure a home semi-final with an emphatic victory at Exeter Braves last time out.
Tom Whiteley scored a hat-trick at Sandy Park and continues at nine, while Max Malins, who also grabbed a try, starts at fly-half.
In the pack, Nick Isiekwe switches to second row to accommodate the returning Sean Reffell, who partners Ben Earl and Sione Vailanu in the back row.
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Hide AdEntry to tonight's game at Allianz Park is free to all supporters.
Saracens Storm: Gallagher; Obatoyinbo, Morris, Griffiths, Segun; Malins, Whiteley; Adams-Hale, Woolstencroft, Judge; Day, Isiekwe; Reffell, Earl, Vailanu.
Replacements: Tolofua, Thompson-Stringer, Figallo, Kpoku, Maka, Taylor, Watson, Bird-Tulloch.
Wanderers: Emery; Sleightholme, Kellaway, Strachan, Pisi; Grayson (c), Davies; Davis, Newman (guest), Painter; Jubb (guest), Carrick-Smith (guest); Coles, Onojaife, Uru.
Replacements: Taylor (guest), Trinder, Ford-Robinson, Betteridge (guest), Laxton (guest), Tupai, Freeman (Under-18s), Worley.